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Sunday, May 10, 2020 | History

2 edition of N-Nitroso Compounds in the Environment (International Agency for Research on Cancer) found in the catalog.

N-Nitroso Compounds in the Environment (International Agency for Research on Cancer)

N-Nitroso Compounds in the Environment (International Agency for Research on Cancer)

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Published by IARC Scientific Publications .
Written in English

    Subjects:
  • Chemistry - General,
  • Science

  • Edition Notes

    ContributionsP. Bogovoski (Editor), E.A. Walker (Editor)
    The Physical Object
    FormatPaperback
    Number of Pages243
    ID Numbers
    Open LibraryOL10137888M
    ISBN 100197230083
    ISBN 109780197230084
    OCLC/WorldCa393105619

    Formation of N-Nitroso Compounds in Foods J. IAN GRAY Chap DOI: /bkch Publication Date (Print): December 9, N-Nitroso-N-methylaniline (NMA) is used in rubber manufacturing and is found in; mutagenic, carcinogenic N-nitroso compounds and methapyrilene hydrochloride. N-nitroso compounds were found in 25 of the 40 facilities including at least 1 facility in each of the 7 industries.

    N-Nitroso-N-butylurea may undergo hydrolysis in the environment based on structurally similar compounds; stability of N-nitroso-N-methylurea and N-nitroso-N-ethylurea in aqueous solutions at 20 °C were reported to be pH dependant with half-lives of to hours at pH values ranging from (2). N-Nitroso compounds, like N-nitroso-N. This vol. is based primarily on original publications and reviews, references to which are contained in the item bibliography. Following a summary of the major issues and recommendations for further studies, the book reviews the chemical properties of nitrates, nitrites and N-nitroso compounds and methods of their analysis; their sources in nature and elsewhere; their transport cycle and.

    Intestinal nitrosation produces ATNCs (Apparent Total N-nitroso Compounds) and these have been linked with an increased risk of colon cancer from eating red meat. Modern LC-MS instrumentation makes direct detection of ATNC components in faecal water a possibility. The difficulty is in determining which of the many compounds present are N-nitrosamines before embarking on efforts to characterise. N-Nitroso-N-methylurea (NMU) is a highly reliable carcinogen, mutagen, and teratogen. NMU is an alkylating agent, and exhibits its toxicity by transferring its methyl group to nucleobases in nucleic acids, which can lead to AT:GC transition mutations.


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N-Nitroso Compounds in the Environment (International Agency for Research on Cancer) Download PDF EPUB FB2

N-Nitroso compounds were known almost 40 years ago to be present in food treated with sodium nitrite, which made fish meal hepatotoxic to animals through formation of nitrosodimethylamine (NDMA).Since that time, N-nitroso compounds have been shown in animal experiments to be the most broadly acting and the most potent group of key role of nitrite and nitrogen oxides in forming Cited by: Get this from a library.

N-nitroso compounds in the factory environment. [David P Rounbehler; John M Fajen; National Institute for Occupational Safety and Health.]. The potential role of dietary intake of N-nitroso compounds and their precursors in the development of cancer is of growing interest ().

N-nitroso compounds risk for human cancer is supported by animal experiments (1,2), and mechanisms describing DNA damage ().Epidemiological studies evaluating the role of N-nitroso compounds have shown a positive association with stomach and upper gastro Cited by: You are here: Home / Book and Report Series / IARC Scientific Publications / N-Nitroso Compounds in the Environment.

N-Nitroso Compounds in the Environment IARC Scientific Publication No. Edited by Bogovski P, Walker EA. ISBN (Print Book) Formats Print Book. Other languages. Lin K, Wu Y, Shen W. Interaction of total N-nitroso compounds in environment and in vivo on risk of esophageal cancer in the coastal area, China.

Environ Int. ; – Lin K, Yu SJ, Zhang JJ, et al. [Study on N-nitroso compound in food and its relevant risk factors for esophageal cancer] Wei Sheng Yan Jiu.

; 34 Cited by: No part of this book may be reproduced in any form without the permission. (N-nitroso compounds), (acrylamide) and (aflatoxin) of this Report.

Biomarkers of health effects. Abstract. The N-nitroso compounds fall into the category of carcinogens discovered through proposed industrial use (Barnes ).

In the early s the then Director of the Medical Research Council’s Toxicology Research Unit, the late Dr. J.M. Barnes, was asked by Dr.

Swaffield to investigate possible toxic hazards from the proposed use of a presumed relatively biologically inert, water Cited by: Click here to obtain permission for The Health Effects of Nitrate, Nitrite, and N-Nitroso Compounds: Part 1 of a 2-Part Study. Translation and Other Rights For information on how to request permission to translate our work and for any other rights related query please click here.

N-Nitroso Compounds in the Environment: IARC Scientific Publication No 9 Out of print IARC: ISBN ISBN X: Order Number Price CHF / US$. Nitroso compound, any of a class of organic compounds having molecular structures in which the nitroso group (-N=O) is attached to a carbon or nitrogen atom.

Substances in which this group is attached to an oxygen atom are called nitrites, that is, esters of nitrous acid; those in which the nitroso group is attached to a metal ion are called nitrosyls. Unfortunately, this book can't be printed from the OpenBook. If you need to print pages from this book, we recommend downloading it as a PDF.

Visit to get more information about this book, to buy it in print, or to download it as a free PDF. N-nitroso compounds in the factory environment (NIOSH technical report) Unknown Binding – January 1, by David P Rounbehler (Author) See all formats and editions Hide other formats and editions.

Enter your mobile number or email address below and we'll send you a link to download the free Kindle App. Author: David P Rounbehler.

Nitroso refers to a functional group in organic chemistry which has the NO group attached to an organic such, various nitroso groups can be categorized as C-nitroso compounds (e.g., nitrosoalkanes; R−N=O), S-nitroso compounds (nitrosothiols; RS−N=O), N-nitroso compounds (e.g., nitrosamines, R 1 N(−R 2)−N=O), and O-nitroso compounds (alkyl nitrites; RO−N=O).

N-nitroso compounds are found in tanneries and plants manufacturing pesticides, rubber products and tires. Other workplaces where N-nitroso compounds are found are fish processing plants, foundries, dye-making plants and research labs.

Rubber baby bottle nipples. This book attempts to demonstrate the complexity of the mechanisms of biological action of the toxic N-nitroso compounds. The conclusions presented on genetic toxicology are based on comparative studies of biological assays and a firm foundation of chemical structural relations among N-nitroso.

Cancer incidences show wide geographic variation and it is likely that chemical carcinogens are responsible for most human cancer. N-Nitroso- (NNO-) compounds cause cancer in experimental animals and could be involved in human cancer, but the level of NNO-compounds so far found in food is generally -compounds are readily formed from nitrite and amines or amides, and the kinetics of Cited by: M.

Tsuda, T. Kakizoe, T. Hirayama and T. Sugimura, New type of N-nitrosamino acids, N-nitroso-L-thioproline and N-nitroso-L-methylthioprolines, found in human urine as major N-nitroso compounds, in: “N-Nitroso Compounds: Occurrence, Biological Effects and Relevance to Human Cancer”, IARC Scientific Publications, No.

57 (). Google ScholarCited by: 1. N-nitroso compounds in the environment. Lyon: International Agency for Research on Cancer, (OCoLC) Material Type: Conference publication, Government publication, International government publication: Document Type: Book: All Authors / Contributors: P Bogovski; E A Walker; International Agency for Research on Cancer.

N-Nitroso-N-methylurea (NMU) is a highly reliable carcinogen, mutagen, and is an alkylating agent, and exhibits its toxicity by transferring its methyl group to nucleobases in nucleic acids, which can lead to AT:GC transition iations: NMU.

N-Nitroso compounds, which include nitrosamines and nitrosamides, have been known for more than years, but nothing was known of their toxicological properties untilwhen Freund described.

Examines the effects of dietary components and other chemopreventive agents on N-nitroso compound metabolism and carcinogenicity. Discusses the use of specific biomarkers of nitrosamine exposure in humans and in animal models and covers their role in the molecular epidemiology of 5/5(2).This book attempts to demonstrate the complexity of the mechanisms of biological action of the toxic N-nitroso compounds.

The conclusions presented on genetic toxicology are based on comparative studies of biological assays and a firm foundation of chemical structural relations among N-nitroso compounds.You are here: Home / Book and Report Series / IARC Scientific Publications / Environmental N-Nitroso Compounds: Analysis and Formation.

Environmental N-Nitroso Compounds: Analysis and Formation IARC Scientific Publication No. Edited by Walker EA, Bogovski P, Griciute L.